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I have demonstrated that BRCA1-mutant triple-negative breast cancer (TNBC) cells are highly sensitive to cyclosporine (CsA) and non-immunosuppressive CsA-derivatives (NIM811 or Alisporivir). To determine whether CsA would also be effective in treating BRCA1-mutant TNBC cells in vivo, I set up a pilot study using a preclinical xenograft model to investigate...

Published: 10/5/2021 | Inventor(s): Kimi Yuk-Ling Kong

Keywords(s):

Category(s): Clinical Specialty > Oncology, Clinical Specialty > Women's Health, Clinical Specialty > Endocrinology, Life Sciences Research Tools > Drug Screening, Therapeutics > Small Molecule

A new approach for treatment of liver cancers

The early stage of hepatocellular carinoma (HCC) tumors (<5cm) can either be excised surgically, or removed byablation therapy, but treatment of advanced stage HCC remain challegning. Since, HCC and other liver cancersare diagnosed at advanced stage, their surgical excision is not feasible. The existing front- and second-linetherapies for advanced...

Published: 9/14/2023 | Inventor(s): Yogesh Gupta

Keywords(s):

Category(s): Clinical Specialty > Oncology, Life Sciences Research Tools > Drug Screening, Therapeutics > Small Molecule, Clinical Specialty > Hepatology