Search Results - Therapeutics

13 Results Sort By:
Radionuclide-loaded Nanoliposomes for Tumor Radiotherapy
Invention Description: Surgical removal of cancerous tissue remains the single best treatment modality for patients with malignant solid tumors. Many solid-tumor cancers, however, are un-resectable or only partially resectable due to the location of the tumor (as in brain cancers) and/or a tumor?s intimate association with un-resectable anat...
Published: 12/18/2017   |   Inventor(s): Ande Bao, Beth Goins, William Phillips
Keywords(s): Imaging
Category(s): Therapeutics
Fabrication of Bone Regeneration Scaffolds and Bone Filler Material Using a Perfusion Flow System
Researchers at UT Health San Antonio have developed a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide...
Published: 4/7/2017   |   Inventor(s): Xiao-Dong Chen
Keywords(s):  
Category(s): Materials and Nanotechnology, Therapeutics
Methods to Produce Novel Analgesic Drugs
The University of Texas Health Science Center at San Antonio (UTHSCSA) seeks to partner with a company interested in developing non-opioid analgesics by exploiting a newly discovered mechanism involved in the pathology of pain. The mechanism also appears to be active in shock and inflammation, so therapeutics with the potential to delay the onset ...
Published: 5/4/2015   |   Inventor(s): Kenneth Hargreaves, Amol Patwardhan, Armen Akopian
Keywords(s):  
Category(s): Therapeutics
Novel Micro RNA as a Tumor Suppressor
The miRNA miR-185 has been shown to inhibit cell proliferation, anchorage independent growth, cell invasion as well as tumor growth and metastasis in immuno-compromised mice. In addition to it success being systemically delivered to treat tumor growth and metastasis in mice, miR-185 sensitizes resistant cancer cells to cancer treatment drugs inclu...
Published: 4/23/2015   |   Inventor(s): Manjeet Rao, J. Saadi Imam
Keywords(s):  
Category(s): Therapeutics
Potential Cancer Therapeutic: TGF-beta Trap
A group of novel pan-TGF-beta inhibitor fusion proteins bind TGF-betas with higher affinity than other compounds currently in preclinical and clinical studies. This TGF-beta antagonist may be useful for treating and/or ameliorating cancer, especially at the metastatic stages. TGF-beta is a potent growth inhibitor in normal epithelial cells by induc...
Published: 4/21/2015   |   Inventor(s): Andrew Hinck, LuZhe Sun, Christian Zwieb
Keywords(s):  
Category(s): Therapeutics
Non-Hydrolysable ATP for Treatment of Primary and Metastatic Cancer
UT Health Science Center San Antonio (UTHSCSA) scientists have discovered that non-hydrolysable forms of ATP reduce cell migration and proliferation in metastatic cancers. ATP (adenosine 5'-triphosphate) has been proposed as a therapeutic agent to improve nutritional status, reduce fatigue, reduce side effects associated with chemotherapy, and pro...
Published: 4/16/2015   |   Inventor(s): Jean Jiang, Jade Zifei Zhou
Keywords(s):  
Category(s): Therapeutics
Use of Capsazepine and Analogs for Treatment of Cancer
A UT Health Science Center San Antonio (UTHSCSA) scientist has discovered that local intra-tumoral injection of Capsazepine offers an effective treatment to reduce tumor cell proliferation in solid tumors. Capsazepine is a known, off-patent, analog of Capsaicin that has been proposed and studied as a TRPV1 antagonist for treatment of pain. Back...
Published: 4/16/2015   |   Inventor(s): Cara Gonzales
Keywords(s):  
Category(s): Therapeutics
In Vivo Methods to Induce Pancreatic Beta Cell Formation for Treatment of Diabetes
University of Texas Health Science Center San Antonio researchers have developed methods for the treatment of Type I and Type II Diabetes Mellitus. The patent-pending technology encompasses in vivo approaches to preferentially increase the number of beta islet (insulin-producing) cells in the adult pancreas without increasing the number of non-ins...
Published: 4/13/2015   |   Inventor(s): Bruno Doiron, Ralph DeFronzo
Keywords(s):  
Category(s): Therapeutics
miRNAs as Novel Therapeutic Adjuvants and Biomarkers for Drug Resistant Breast Cancers
Researchers at UT Health San Antonio have identified a microRNA that can uniquely sensitize drug-resistant, triple-negative breast cancer to chemotherapy drugs such as paclitaxel, providing a novel and potent potential therapeutic approach with lower toxicity and reduced side effects. Overview Disease-free survival is short-lived for women with tri...
Published: 4/10/2015   |   Inventor(s): Manjeet Rao, J. Saadi Imam, Behyar Zoghi, Yao-Fu-Chang, Panneerdoss Subbarayalu
Keywords(s):  
Category(s): Therapeutics
Allosteric Proteasome Inhibitors for Treatment of Cancer
UT Health San Antonio scientists have discovered novel small-molecule compounds that have allosteric signaling activity to modulate proteasome catalytic activity. The allosteric proteasome inhibitors can be used alone or in combination with existing competitive proteasome inhibitors for treatment of cancer. Studies of combination treatment demons...
Published: 4/10/2015   |   Inventor(s): Pawel Osmulski, Maria Gaczynska
Keywords(s):  
Category(s): Therapeutics
1 2