Method and Apparatus for Stent Deployment with Enhanced Delivery of Bio-Active Agents

Tech ID:
1998.011.HSCS
Description:

A stent for use in animals including humans is disclosed which includes unprotected and protected regions, each protected regions including a bioactive or biopenetrating agent containing therein where the protected regions are protected by the unprotected regions when the stent is in its undeployed state which has a smaller cross-sectional dimension than the stent in its deployed state. And when the stent is in its deployed state the bioactive or biopenetrating agent(s) are brought into direct and intimate contact with a tissue or interior of a blood vessel of an animal including a human.

 

Summary of the Invention

 

The present invention provides stents for treating, expanding and/or supporting a portion of a vessel or for treating a tissue site, when the stent is inserted into the vessel or tissue site. The stents include at least one or one or more recessed region and at least one or one or more non-recessed region. One or more of the recessed regions can contain:

 

1)       a bioactive composition designed to chemically or biochemically interact with the interior of the vessel or the tissue site to cause a prophylactic and/or therapeutic effect;

 

2)       a penetrating apparatus or structure designed to mechanically or physically interact with the interior of the vessel or the tissue site to cause a prophylactic and/or therapeutic effect; or

 

3)       a mixture or combination thereof. The stents have a deployed and non-deployed state that can be the same or different. In the deployed state, the recessed regions can remain recessed, become essentially flush with the non-recessed regions, protrude above the non-recessed regions and/or include portions that remain recessed relative to the non-recessed regions, protrude above the non-recessed regions or are essentially flush with the non-recessed regions. The term essentially flush means that in the deployed state, the non-recessed and recessed regions form an essentially continuous surface.

 

Inventors:  Marc D. Feldman, Stephen R. Bailey,  C Mauli Agrawal, Kyriacos A. Athanasiou

 

Issued U.S. Patent Number: 7,238,199

Priority Date:       2001-03-06

Link to Full Text of Patent:  http://patft.uspto.gov/netacgi/nph-Parser?patentnumber=7,238,199

 

 
Patent Information:
For information contact:
John Fritz
Sr. Business Development Manager
Office of Technology Commercialization
FRITZJA@UTHSCSA.EDU
Inventors:
Marc Feldman
Kyriacos Athanasiou
C. Mauli Agrawal
Steven Bailey
Keywords:
Biologics
Medical Devices