Fabrication of Bone Regeneration Scaffolds and Bone Filler Material Using a Perfusion Flow System

Tech ID:
HSC-1384
Description:

Fabrication Of Bone Regeneration Scaffolds And Bone Filler Material Using A Perfusion Flow System

 

Tech ID:

HSC-1384

 

Description:

U.S. Patent Issued

9,044,530

Xiao-Dong Chen, et al.

Issued 06/02/2015


 

Abstract

The present disclosure is directed at a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.

 

Issued Patent:

9,044,530
Patent Information:
For information contact:
John Fritz
Sr. Business Development Manager
Office of Technology Commercialization
FRITZJA@UTHSCSA.EDU
Inventors:
Xiao-Dong Chen
Keywords: