Fabrication of Bone Regeneration Scaffolds and Bone Filler Material Using a Perfusion Flow System

Tech ID:

Researchers at UT Health San Antonio have developed a process to form bone grafting material. One may provide a porous collagen scaffold and insert the scaffold into a perfusion chamber of a perfusion flow system. This may then be followed by continuously providing a mineralization perfusion fluid flow through the scaffold at a flow rate to provide dynamic intrafibrillar mineralization of the scaffold and form a collagen/hydroxyapatite composite scaffold. One may optionally provide the scaffold with bone tissue forming cells and then deliver a perfusion fluid including oxygen and one or more nutrients through the collagen/hydroxyapatite composite scaffold and to the bone tissue forming cells at a flow rate such that the bone tissue forming cells remodel the collagen/hydroxyapatite composite scaffold and form a bone tissue extracellular matrix. The bone tissue extracellular matrix may then be decellularized to form an acellular bone repair scaffold.


IP Status:     Patent 9,044,530, Issued 06/02/2015

Patent Information:
For information contact:
John Fritz
Sr. Business Development Manager
Office of Technology Commercialization
Xiao-Dong Chen