TMEPAI for Diagnosis and Treatment of Breast Cancer

Tech ID:
2012.063.HSCS

UT Health San Antonio researchers have developed an assay that detects overexpression of TMEPAI, a potential biomarker for aggressive cancer growth and invasion in TNBC patients.  Dr. Saikumar’s team has identified compounds that inhibit the expression of TMEPAI and thus may represent therapeutic candidates to inhibit cancer proliferation and metastasis.  In vitro and in vivo preclinical studies with these agents have confirmed activity resulting in reduced expression of TMEPAI, elevated expression of TGF- β tumor suppressor signaling, decreased cancer cell proliferation, and increased cancer cell death. 

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Inventors:
Pothana Saikumar
Prajjal Singha
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