Search Results - liqin+du

1 Results

Sort By:

MicroRNA mimics as potential differentiation agents for treating neuroblastoma

Neuroblastoma,themostcommonextracranialsolidtumorofchildhood,arisesfromneuralcrestcellprecursorsthatfailtodifferentiate.Inducingcelldifferentiationisanimportanttherapeuticstrategyforneuroblastoma.Wedevelopedadirectfunctionalhigh-‐contentscreentoidentifydifferentiation-‐inducingmicroRNAs,inordertodevelopmicroRNA-‐baseddifferentiationtherapyforneuroblastoma.WediscoverednovelmicroRNAs,andmorestrikingly,threemicroRNAseedfamiliesthatinduceneuroblastomacelldifferentiation.Inaddition,weshowedthatmicroRNAseedfamilieswereoverrepresentedintheidentifiedgroupoffourteendifferentiation-‐inducingmicroRNAs,suggestingthatmicroRNAseedfamiliesarefunctionallymoreimportantinneuroblastomadifferentiationthanmicroRNAswithuniquesequences.Wefurtherinvestigatedthedifferentiation-‐inducingfunctionofthemicroRNA-‐506-‐3p/microRNA-‐124-‐3pseedfamily,whichwasthemostpotentinducerofdifferentiation.Weshowedthatthedifferentiation-‐inducingfunctionofmicroRNA-‐506-‐3p/microRNA-‐124-‐3pismediated,atleastpartially,bydown-‐regulatingexpressionoftheirtargetsCDK4andSTAT3.WefurthershowedthatexpressionofmiR-‐506-‐3p,butnotmiR-‐124-‐3p,isdramaticallyup...

Published: 9/14/2023 | Inventor(s): Liqin Du, Alexander Pertsemlidis

Keywords(s):

Category(s): Clinical Specialty > Oncology, Clinical Specialty > Neurology, Therapeutics > miRNA