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Pharmacological manipulation of M-type (KCNQ, Kv7) potassium currents as a therapeutic target for treatment of addiction
Members of KCNQ2-5 (Kv7.2-7.5) K+ channel subunits underlie the neuronal M-type K+ current, a critical regulator of neuronal excitability, including resting membrane potential, threshold excitability and spike bursting. Inhibition of M-type channels is excitatory, whereas their augmentation usually has an inhibitory, silencing effect. M current has...
Published: 9/14/2023   |   Inventor(s): Fabio Antonio Borges Vigil, Mark Shapiro
Keywords(s):  
Category(s): Clinical Specialty > Neurology, Clinical Specialty > Psychology, Therapeutics > Small Molecule