Prevention of epileptic seizures by targeting canonical transient receptor potential (TRPC) channels in the brain

Tech ID:
HSC-1577

10 mg/kg (i.p.) M084 hydrochloride was administered 30 minutes prior to a widely used model of seizure induction in mice (pilocarpine-induced seizure). The TRPC channel antagonist significantly blocked seizure activity, compared to vehicle-injected control animals. We will investigate TRPC channel block for control of seizures in multiple mouse models including chemoconvulsant-induced seizure and traumatic brain injury-induced seizure.

Category(s):
Neurology
Small Molecule
For information contact:
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Inventors:
Chase Carver
Patent Information:
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