Search Results - chase+carver

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Prevention of epileptic seizures by targeting canonical transient receptor potential (TRPC) channels in the brain
10 mg/kg (i.p.) M084 hydrochloride was administered 30 minutes prior to a widely used model of seizure induction in mice (pilocarpine-induced seizure). The TRPC channel antagonist significantly blocked seizure activity, compared to vehicle-injected control animals. We will investigate TRPC channel block for control of seizures in multiple mouse models...
Published: 1/27/2021   |   Inventor(s): Chase Carver
Category(s): Clinical Specialty > Neurology, Therapeutics > Small Molecule