Search Results - Clinical+Specialty+%3e+Neurology

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Prevention of epileptic seizures by targeting canonical transient receptor potential (TRPC) channels in the brain
10 mg/kg (i.p.) M084 hydrochloride was administered 30 minutes prior to a widely used model of seizure induction in mice (pilocarpine-induced seizure). The TRPC channel antagonist significantly blocked seizure activity, compared to vehicle-injected control animals. We will investigate TRPC channel block for control of seizures in multiple mouse models...
Published: 1/27/2021   |   Inventor(s): Chase Carver
Keywords(s):  
Category(s): Clinical Specialty > Neurology, Therapeutics > Small Molecule
Closed-loop continuous sodium monitoring and hypertonic saline administration system
The device is a closed-loop continuous sodium monitor combined with an infusion pump that automatically adjusts hypertonic saline administration according to the serum sodium. For the initial prototype, an ion-specific electrode will be used for continuous sodium monitoring. We will also develop a noninvasive sensor for continuous sodium monitoring...
Published: 2/21/2020   |   Inventor(s): Geoffrey Peitz, William D'Angelo, Ashley Dacy
Keywords(s):  
Category(s): Clinical Specialty > Emergency Medicine, Clinical Specialty > Neurology, Medical Devices > Monitoring Equipment, Software and Computer > Algorithms
Pharmacological manipulation of M-type (KCNQ, Kv7) potassium currents as a therapeutic target for treatment of addiction
Members of KCNQ2-5 (Kv7.2-7.5) K+ channel subunits underlie the neuronal M-type K+ current, a critical regulator of neuronal excitability, including resting membrane potential, threshold excitability and spike bursting. Inhibition of M-type channels is excitatory, whereas their augmentation usually has an inhibitory, silencing effect. M current has...
Published: 2/14/2020   |   Inventor(s): Fabio Antonio Borges Vigil, Mark Shapiro
Keywords(s):  
Category(s): Clinical Specialty > Neurology, Clinical Specialty > Psychology, Therapeutics > Small Molecule
PET Tracers for alpha-synuclein ( a-syn) Imaging
There are no known specific ligands for alpha-synuclein PET imaging. Molecular docking studies were carried out with beta-Amyloid and tau proteins. We found ten molecules that sowed higher affinity towards alpha-synuclein over beta-Amyloid and tau.Our goal is to find a alpha-synuclein lead PET ligand by in vitro and in vivo studies. These will be placed...
Published: 2/14/2020   |   Inventor(s): Ramesh Neelamegam
Keywords(s):  
Category(s): Diagnostics > Assay, Clinical Specialty > Aging/Gerontology, Medical Devices > Imaging, Clinical Specialty > Neurology
MicroRNA mimics as potential differentiation agents for treating neuroblastoma
Neuroblastoma,themostcommonextracranialsolidtumorofchildhood,arisesfromneuralcrestcellprecursorsthatfailtodifferentiate.Inducingcelldifferentiationisanimportanttherapeuticstrategyforneuroblastoma.Wedevelopedadirectfunctionalhigh-­‐contentscreentoidentifydifferentiation-­‐inducingmicroRNAs,inordertodevelopmicroRNA-­‐baseddifferentiationtherapyforneuroblastoma.WediscoverednovelmicroRNAs,andmorestrikingly,threemicroRNAseedfamiliesthatinduceneuroblastomacelldifferentiation.Inaddition,weshowedthatmicroRNAseedfamilieswereoverrepresentedintheidentifiedgroupoffourteendifferentiation-­‐inducingmicroRNAs,suggestingthatmicroRNAseedfamiliesarefunctionallymoreimportantinneuroblastomadifferentiationthanmicroRNAswithuniquesequences.Wefurtherinvestigatedthedifferentiation-­‐inducingfunctionofthemicroRNA-­‐506-­‐3p/microRNA-­‐124-­‐3pseedfamily,whichwasthemostpotentinducerofdifferentiation.Weshowedthatthedifferentiation-­‐inducingfunctionofmicroRNA-­‐506-­‐3p/microRNA-­‐124-­‐3pismediated,atleastpartially,bydown-­‐regulatingexpressionoftheirtargetsCDK4andSTAT3.WefurthershowedthatexpressionofmiR-­‐506-­‐3p,butnotmiR-­‐124-­‐3p,isdramaticallyup...
Published: 12/13/2019   |   Inventor(s): Liqin Du, Alexander Pertsemlidis
Keywords(s):  
Category(s): Clinical Specialty > Oncology, Clinical Specialty > Neurology, Therapeutics > miRNA
Gene Transfer to Improve Cognitive Dysfunction in Alzheimer’s Disease
University of Texas Health Science Center at San Antonio researchers have developed a unique therapeutic approach which could restore learning and memory ability in those afflicted with Alzheimer’s Disease and other neurodegenerative diseases. Abnormalities in the expression of cAMP-response element binding protein (CREB) have been reported in...
Published: 1/16/2019   |   Inventor(s): Salvatore Oddo, Antonella Caccamo
Keywords(s):  
Category(s): Clinical Specialty > Neurology, Therapeutics > Small Molecule
Micro-RNA Therapy for High-Risk Pediatric Brain Cancer
A MicroRNA therapy has been developed for the purpose of increasing the chemo- and radio-sensitivity of tumor cells in Medulloblastoma. The invention would allow for lower dosages of radiation and chemotherapy by working synergistically with these therapies, thus reducing adverse side effects. It may also lead to more complete eradication of the tumor...
Published: 9/25/2018   |   Inventor(s): Manjeet Rao, Nourhan Abdelfattah
Keywords(s):  
Category(s): Therapeutics > Biologics, Therapeutics > Nucleic Acids, Clinical Specialty > Neurology, Clinical Specialty > Oncology, Clinical Specialty > Pediatrics
Glow Bright
Small, fluorescent surgical disposables (i.e. needles, sutures, and trocars) have been invented by UT Health SA that fluoresce to aid in visualization of the item. This functionality can be used in the event that the items are lost or unaccounted for during or after a surgical procedure. Background:Losing an instrument during surgery is a rare but...
Published: 9/20/2018   |   Inventor(s): Kinley Beck, Jeong-Hyeon Sohn, Petar Yanev, Joshua Iltis
Keywords(s):  
Category(s): Clinical Specialty > Opthamology, Medical Devices > Consumables, Medical Devices > Surgical Equipment, Clinical Specialty > Neurology
Antipsychotic Drugs to Reduce the Abuse Liability of Opioids
This invention is a novel use of “atypical” antipsychotic drugs in combination with opioids to reduce the abuse potential of the opioid pain medication. The abuse potential is reduced by inhibiting the stimulation of the reward center in the brain.Background:The global pain market is estimated to reach $21.6 billion USD in 2022 and an estimated...
Published: 8/14/2018   |   Inventor(s): Daniel Lodge, Alan Frazer
Keywords(s):  
Category(s): Clinical Specialty > Neurology, Clinical Specialty > Pain Management, Therapeutics > Analgesics
Intravenous Tramadol for Treatment of anti-NMDA Encephalitis
The invention is a combinatorial therapy used to enhance the efficacy of plasma exchange (PLEX) in treating patients with anti-NMDAR encephalitis. This treatment regimen would treat both the psychiatric and immunological manifestations of this disorder and substantially lower the patients’ recovery periods. Background:Anti-NMDAR encephalitis is...
Published: 4/20/2018   |   Inventor(s): Ali Seifi
Keywords(s):  
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Neurology, Clinical Specialty > Oncology, Clinical Specialty > Immunology