Search Results - Clinical Specialty > Oncology

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Novel Compounds to Inhibit Cancer, Cancer Metastasis, and Autoimmune Diseases
Several candidate small molecules have been discovered that show dose-dependent anti-cancer effects in vitro. These compounds each have one of the following characteristics: (1) non-hydrolyzable ATP analog or (2) adenosine receptor antagonist. Testing of these compounds has demonstrated successful inhibition of cancer cell migration. Additionally...
Published: 5/22/2018   |   Inventor(s): Jean Jiang
Keywords(s):  
Category(s): Clinical Specialty > Immunology, Clinical Specialty > Oncology, Therapeutics > Small Molecule
Intravenous Tramadol for Treatment of anti-NMDA Encephalitis
The invention is a combinatorial therapy used to enhance the efficacy of plasma exchange (PLEX) in treating patients with anti-NMDAR encephalitis. This treatment regimen would treat both the psychiatric and immunological manifestations of this disorder and substantially lower the patients’ recovery periods. Background:Anti-NMDAR encephalitis ...
Published: 4/20/2018   |   Inventor(s): Ali Seifi
Keywords(s):  
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Neurology, Clinical Specialty > Oncology, Clinical Specialty > Immunology
Combination of DHA and HDACIs in treating Prostate Cancer
The disclosed invention is a proposed combination therapy to treat prostate cancer, especially prostate cancer patients with biochemical recurrence (BCR). The combination therapy is composed of UTH1, a fatty acid compound with Generally Recognized As Safe (GRAS) status, and Valproic Acid (VPA), a generic drug with clinical use since 1963 as a mood ...
Published: 3/9/2018   |   Inventor(s): Wasim Chowdhury, Ronald Rodriguez, Md Rahman
Keywords(s):  
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Oncology, Clinical Specialty > Reproductive Health, Clinical Specialty > Urology
ANGPTL4 as prognostic marker for bladder cancer
Researchers at UT Health SA have discovered a less invasive method to monitor for recurrence of bladder cancer. Using Angiopoietin-like 4 protein (ANGPTL4) as a prognostic indicator, clinicians would be able to use a urine sample to monitor the likelihood of recurrence of non-muscle invasive bladder cancer. Background:Non-muscle invasive bladder ca...
Published: 3/6/2018   |   Inventor(s): Rita Ghosh, Roble Bedolla, Eduardo Cardenas, Neelam Mukherjee, Tiffani Houston
Keywords(s):  
Category(s): Diagnostics > Biomarkers, Clinical Specialty > Oncology, Clinical Specialty > Urology
DNA Double-Strand-Break Dosimeter for Radiation Therapy
A unique radiation dosimeter to directly measure biological damage from radiotherapy has been developed at UT Health San Antonio to greatly the improve accuracy of radiotherapy doses for certain challenging clinical scenarios.Background:Radiotherapy is an important tool in the arsenal of anti-cancer treatments as it generates Double-Strand-Breaks (...
Published: 3/6/2018   |   Inventor(s): Neil Kirby, Eun Yong Shim, Sang Lee
Keywords(s):  
Category(s): Medical Devices > Monitoring Equipment, Other > Testing/Calibration Equipment, Clinical Specialty > Oncology, Clinical Specialty > Radiology
Novel Micro RNA as a Tumor Suppressor
The miRNA miR-185 has been shown to inhibit cell proliferation, anchorage independent growth, cell invasion as well as tumor growth and metastasis in immuno-compromised mice. In addition to it success being systemically delivered to treat tumor growth and metastasis in mice, miR-185 sensitizes resistant cancer cells to cancer treatment drugs inclu...
Published: 4/23/2015   |   Inventor(s): Manjeet Rao, J. Saadi Imam
Keywords(s):  
Category(s): Therapeutics > Biologics, Clinical Specialty > Oncology
Non-Hydrolysable ATP for Treatment of Cancer
UT Health San Antonio scientists have discovered that non-hydrolysable forms of ATP reduce cell migration and proliferation in metastatic cancers.Background:ATP (adenosine 5'-triphosphate) has been proposed as a therapeutic agent to improve nutritional status, reduce fatigue, reduce side effects associated with chemotherapy, and promote overall qua...
Published: 4/16/2015   |   Inventor(s): Jean Jiang, Jade Zifei Zhou
Keywords(s):  
Category(s): Therapeutics > Biologics, Clinical Specialty > Oncology
miRNAs for Treatment of Drug Resistant Breast Cancers
Researchers at UT Health San Antonio have identified a microRNA that can uniquely sensitize drug-resistant, triple-negative breast cancer to chemotherapy drugs such as paclitaxel, providing a novel and potent potential therapeutic approach with lower toxicity and reduced side effects.BackgroundDisease-free survival is short-lived for women with tri...
Published: 4/10/2015   |   Inventor(s): Manjeet Rao, J. Saadi Imam, Behyar Zoghi, YaO-FU-Chang, Panneerdoss Subbarayalu
Keywords(s):  
Category(s): Life Sciences Research Tools > Biomarkers, Therapeutics > Biologics, Clinical Specialty > Oncology, Clinical Specialty > Women's Health
Allosteric Proteasome Inhibitors for Treatment of Cancer
UT Health San Antonio scientists have discovered novel small-molecule compounds that have allosteric signaling activity to modulate proteasome catalytic activity. The allosteric proteasome inhibitors can be used alone or in combination with existing competitive proteasome inhibitors for the treatment of cancer. Studies of combination treatment de...
Published: 4/10/2015   |   Inventor(s): Pawel Osmulski, Maria Gaczynska
Keywords(s):  
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Oncology
Novel Inhibitor of Proto-Oncogene PELP1
Novel peptide inhibitors that disrupts the functional interactions of oncogenic protein PELP1 have been discovered by researchers at UT Health San Antonio. These inhibitors can be used for treatment of cancers that are characterized as over-expressing PELP1.Background:PELP1 overexpression, noted in many hormone-related cancers such as breast, prost...
Published: 4/10/2015   |   Inventor(s): Ratna Vadlamudi, Monica Mann, Samaya Krishnan, Gangadhara Sareddy
Keywords(s):  
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Oncology
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