Search Results - Therapeutics+%3e+Small+Molecule

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TMEPAI for Diagnosis and Treatment of Breast Cancer
UT Health San Antonio researchers have developed an assay that detects overexpression of TMEPAI, a potential biomarker for aggressive cancer growth and invasion in TNBC patients. Dr. Saikumar’s team has identified compounds that inhibit the expression of TMEPAI and thus may represent therapeutic candidates to inhibit cancer proliferation and...
Published: 3/26/2021   |   Inventor(s): Pothana Saikumar, Prajjal Singha
Category(s): Clinical Specialty > Oncology, Clinical Specialty > Women's Health, Diagnostics > Biomarkers, Therapeutics > Small Molecule
Prevention of epileptic seizures by targeting canonical transient receptor potential (TRPC) channels in the brain
10 mg/kg (i.p.) M084 hydrochloride was administered 30 minutes prior to a widely used model of seizure induction in mice (pilocarpine-induced seizure). The TRPC channel antagonist significantly blocked seizure activity, compared to vehicle-injected control animals. We will investigate TRPC channel block for control of seizures in multiple mouse models...
Published: 1/27/2021   |   Inventor(s): Chase Carver
Category(s): Clinical Specialty > Neurology, Therapeutics > Small Molecule
Oxytocin to prevent, reduce and reverse Opioid-Induced Respiratory Depression
The use of opioids can result in lethal overdose caused by respiratory depression, but the mechanisms of opioid induced respiratory depression (OIRD) remain to be elucidated. The only currently available, FDA approved, treatment for OIRD is the opioid receptor antagonist naloxone (Narcan). The foremost limitation of using naloxone to combat OIRD...
Published: 10/15/2020   |   Inventor(s): Glenn Toney, Allison Brackley
Category(s): Clinical Specialty > Pulmonology, Clinical Specialty > Pain Management, Clinical Specialty > Sleep Disorders, Clinical Specialty > Ear, Nose, Throat, Therapeutics > Analgesics, Therapeutics > Small Molecule
Discovery of a METTL3 inhibitor
METTL3 Inhibitors as Leukemia therapeuticsTHE PROBLEM Acute Myeloid LeukemiaAcute myeloid leukemia (AML) is a relatively rare cancer (1% of all cancer incidence cases), however it accounts for a disproportionally high number of cancer-related deaths. AML’s lethality can be contributed to its fast progression, low survivability, and high rate of...
Published: 5/7/2020   |   Inventor(s): Yogesh Gupta
Category(s): Clinical Specialty > Oncology, Therapeutics > Small Molecule
An improved muscarinic-antagonist antidepressant
Scopolamine, a non-selective muscarinic antagonist, is a rapidly effective antidepressant compoundin humans likely mediated through an antimuscarinic effect. Unfortunately, scopolamine canproduce cognitive impairment including memory disturbances in humans. It is our goal to identifya muscarinic antagonist that may be able to relieve depression without...
Published: 3/30/2020   |   Inventor(s): James Woods, Andrew Coop, Chad Johnson, Jack Bergman, Emily Jutkiewicz, Brian Kangas
Category(s): Clinical Specialty > Psychiatry, Therapeutics > Small Molecule
New approach for treating functional dyspepsia
My inventive idea is to use a therapeutic molecule that slows gastric emptying for the treatment of functional dyspepsia in non-diabetic patients. This contrarian idea is based on our research of gastric emptying which shows that 30% of non-diabetic patients referred for gastric emptying studies due to gastrointestinal symptoms have elevated postprandial...
Published: 3/10/2020   |   Inventor(s): William Phillips
Category(s): Clinical Specialty > Gastroenterology, Food Science > Nutrition, Therapeutics > Small Molecule
Pharmacological manipulation of M-type (KCNQ, Kv7) potassium currents as a therapeutic target for treatment of addiction
Members of KCNQ2-5 (Kv7.2-7.5) K+ channel subunits underlie the neuronal M-type K+ current, a critical regulator of neuronal excitability, including resting membrane potential, threshold excitability and spike bursting. Inhibition of M-type channels is excitatory, whereas their augmentation usually has an inhibitory, silencing effect. M current has...
Published: 2/14/2020   |   Inventor(s): Fabio Antonio Borges Vigil, Mark Shapiro
Category(s): Clinical Specialty > Neurology, Clinical Specialty > Psychology, Therapeutics > Small Molecule
Dopamine 2 Receptor agonists as new therapeutics for Age Related Macular Degeneration and Diabetic Retinopathy
By understanding and controlling activation of specific dopamine receptors, we showed that the current dopamine pathway drugs can be used in new ways as new therapeutics to treat wet age-related macular degeneration (ARMD) and diabetic retinopathy (DR). It will reduce the chance of a side effect of conventional ARMD or DR therapy, leading to vision...
Published: 2/14/2020   |   Inventor(s): Jeong-Hyeon Sohn, Rene Renteria, Nikolay Akimov
Category(s): Clinical Specialty > Opthamology, Therapeutics > Small Molecule
CsA treatment for BRCA1 mutant cancers
I have demonstrated that BRCA1-mutant triple-negative breast cancer (TNBC) cells are highly sensitive to cyclosporine (CsA) and non-immunosuppressive CsA-derivatives (NIM811 or Alisporivir). To determine whether CsA would also be effective in treating BRCA1-mutant TNBC cells in vivo, I set up a pilot study using a preclinical xenograft model to investigate...
Published: 2/14/2020   |   Inventor(s): Kimi Yuk-Ling Kong
Category(s): Clinical Specialty > Oncology, Clinical Specialty > Women's Health, Clinical Specialty > Endocrinology, Life Sciences Research Tools > Drug Screening, Therapeutics > Small Molecule
A new approach for treatment of liver cancers
The early stage of hepatocellular carinoma (HCC) tumors (<5cm) can either be excised surgically, or removed byablation therapy, but treatment of advanced stage HCC remain challegning. Since, HCC and other liver cancersare diagnosed at advanced stage, their surgical excision is not feasible. The existing front- and second-linetherapies for advanced...
Published: 2/14/2020   |   Inventor(s): Yogesh Gupta
Category(s): Clinical Specialty > Oncology, Life Sciences Research Tools > Drug Screening, Therapeutics > Small Molecule, Clinical Specialty > Hepatology
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