Search Results - therapeutics > small molecule

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Gene Transfer to Improve Cognitive Dysfunction in Alzheimer’s Disease
University of Texas Health Science Center at San Antonio researchers have developed a unique therapeutic approach which could restore learning and memory ability in those afflicted with Alzheimer’s Disease and other neurodegenerative diseases. Abnormalities in the expression of cAMP-response element binding protein (CREB) have been reported in...
Published: 1/16/2019   |   Inventor(s): Salvatore Oddo, Antonella Caccamo
Category(s): Clinical Specialty > Neurology, Therapeutics > Small Molecule
Novel Polygodial Analogs to Treat Cancer
Novel polygodial analogs for the treatment of cancer and other proliferative diseases have been developed by researchers at UT Health San Antonio. These analogs are effective in inhibiting cell proliferation both in vitro and in vivo, without the observable side effects attributed to the parent compound. Moreover, these analogs may have potential a...
Published: 10/16/2018   |   Inventor(s): Cara Gonzales, Alex Kornienko, Ramesh Dasari
Category(s): Clinical Specialty > Dentistry, Clinical Specialty > Oncology, Therapeutics > Small Molecule
PARP-1 Inhibitor Nanoparticle and Treatment Method for Ewing Sarcoma
A novel nanoparticle formulation of an existing PARP-1 inhibitor and an associated administration regimen has been developed for the treatment of Ewing Sarcoma. This technology allows the therapeutic treatment to be targeted to the tumors, resulting in reduced required doses and system toxicity.Background:Ewing Sarcoma is rare cancer of the bone t...
Published: 10/10/2018   |   Inventor(s): Raushan Kurmasheva, Kytai Nguyen
Category(s): Clinical Specialty > Orphan Diseases, Clinical Specialty > Orthopedics, Therapeutics > Nanoparticles, Clinical Specialty > Oncology, Therapeutics > Small Molecule
Novel Capsazepine Analogs to Treat Cancer
Novel compounds have been developed based upon the capsazepine pharmacophore that are effective in halting tumor cell proliferation in vitro and in vivo. Capsazepine is a known, off-patent, analog of Capsaicin that has been proposed and studied as a TRPV1 antagonist for treatment of pain. Although Capsazepine has been proposed for alleviation of p...
Published: 8/23/2018   |   Inventor(s): Cara Gonzales, Stanton McHardy
Category(s): Clinical Specialty > Oncology, Therapeutics > Small Molecule
Novel Compounds to Inhibit Cancer, Cancer Metastasis, and Autoimmune Diseases
Several candidate small molecules have been discovered that show dose-dependent anti-cancer effects in vitro. These compounds each have one of the following characteristics: (1) non-hydrolyzable ATP analog or (2) adenosine receptor antagonist. Testing of these compounds has demonstrated successful inhibition of cancer cell migration. Additionally...
Published: 5/22/2018   |   Inventor(s): Jean Jiang
Category(s): Clinical Specialty > Immunology, Clinical Specialty > Oncology, Therapeutics > Small Molecule
Intravenous Tramadol for Treatment of anti-NMDA Encephalitis
The invention is a combinatorial therapy used to enhance the efficacy of plasma exchange (PLEX) in treating patients with anti-NMDAR encephalitis. This treatment regimen would treat both the psychiatric and immunological manifestations of this disorder and substantially lower the patients’ recovery periods. Background:Anti-NMDAR encephalitis ...
Published: 4/20/2018   |   Inventor(s): Ali Seifi
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Neurology, Clinical Specialty > Oncology, Clinical Specialty > Immunology
Combination of DHA and HDACIs in treating Prostate Cancer
The disclosed invention is a proposed combination therapy to treat prostate cancer, especially prostate cancer patients with biochemical recurrence (BCR). The combination therapy is composed of UTH1, a fatty acid compound with Generally Recognized As Safe (GRAS) status, and Valproic Acid (VPA), a generic drug with clinical use since 1963 as a mood ...
Published: 3/9/2018   |   Inventor(s): Wasim Chowdhury, Ronald Rodriguez, Md Rahman
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Oncology, Clinical Specialty > Reproductive Health, Clinical Specialty > Urology
Allosteric Proteasome Inhibitors for Treatment of Cancer
UT Health San Antonio scientists have discovered novel small-molecule compounds that have allosteric signaling activity to modulate proteasome catalytic activity. The allosteric proteasome inhibitors can be used alone or in combination with existing competitive proteasome inhibitors for the treatment of cancer. Studies of combination treatment de...
Published: 4/10/2015   |   Inventor(s): Pawel Osmulski, Maria Gaczynska
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Oncology
Novel Inhibitors of Proto-Oncogene PELP1
Novel peptide inhibitors that disrupts the functional interactions of oncogenic protein PELP1 have been discovered by researchers at UT Health San Antonio. These inhibitors can be used for treatment of cancers that are characterized as over-expressing PELP1.Background:PELP1 overexpression, noted in many hormone-related cancers such as breast, prost...
Published: 4/10/2015   |   Inventor(s): Ratna Vadlamudi, Monica Mann, Samaya Krishnan, Gangadhara Sareddy
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Oncology
Salvinia Cyctotoxic Compounds for Treatment of Cancer
Novel plant-derived compounds that have cytotoxic properties against cancer cells and therefore may be potent anticancer therapeutics have been discovered by UT Health San Antonio researchers. These compounds are derived from giant salvinia, one of the most noxious invasive species of plants in the world. The compounds showed selective cytotoxic ac...
Published: 4/23/2013   |   Inventor(s): Shiyou Li, Ping Wang, Guangrui Deng, Wei Yuan, Zushang Su
Keywords(s): Drugs
Category(s): Therapeutics > Small Molecule, Clinical Specialty > Oncology